Corticotropin-releasing hormone programs the fetal and maternal brain
نویسندگان
چکیده
منابع مشابه
Maternal Lipopolysaccharide Induces Cytokines in the Amniotic Fluid and Corticotropin Releasing Hormone in the Fetal Rat Brain
Running Head: Maternal infection induces cytokines in fetal environment All correspondence to: Dave A. Gayle, Ph.D. Department of Obstetrics and Gynecology, Harbor-UCLA Medical Center and Research and Education Institute, RB-1, Box 446, Torrance, CA 90502. Phone: 310-222-1976; Fax: 310-222-4131; email: [email protected] Acknowledgements: This work was supported by funding from NIH RO1 DK43311 and...
متن کاملMaternal LPS induces cytokines in the amniotic fluid and corticotropin releasing hormone in the fetal rat brain.
Perinatal infections are a risk factor for fetal neurological pathologies, including cerebral palsy and schizophrenia. Cytokines that are produced as part of the inflammatory response are proposed to partially mediate the neurological injury. This study investigated the effects of intraperitoneal injections of lipopolysaccharide (LPS) to pregnant rats on the production of cytokines and stress m...
متن کاملEndocrinology and the brain: corticotropin-releasing hormone signaling
Corticotropin-releasing hormone (CRH) is a key player of basal and stress-activated responses in the hypothalamic-pituitary-adrenal axis (HPA) and in extrahypothalamic circuits, where it functions as a neuromodulator to orchestrate humoral and behavioral adaptive responses to stress. This review describes molecular components and cellular mechanisms involved in CRH signaling downstream of its G...
متن کاملCorticotropin-releasing hormone and the blood-brain-barrier.
Increased blood-brain-barrier (BBB) permeability precedes any clinical or pathologic signs and is critical in the pathogenesis of multiple sclerosis (MS) and brain metastases. CD4+ TH1 cells mediate demyelination in MS, but how they get sensitized and enter the brain to induce brain inflammation remains obscure. TH2 cytokines associated with allergic disorders have recently been implicated in M...
متن کاملCorticotropin-releasing hormone physiology
Corticotropin-releasing hormone (CRH), also known as corticotropin-releasing factor, is a highly conserved peptide hormone comprising 41 amino acid residues. Its name derives from its role in the anterior pituitary, where it mediates the release of corticotropin (ACTH) leading to the release of adrenocortical steroids. CRH is the major hypothalamic activator of the hypothalamic–pituitary– adren...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Future Neurology
سال: 2009
ISSN: 1479-6708,1748-6971
DOI: 10.2217/fnl.09.8